We are seeking an outstanding Antibody and Protein Engineer for a Principal Scientist position within the Immunobiologics group at Takeda California. The role is a hands-on lab-based research scientist with technical expertise in the field of protein engineering and display technologies that may include monoclonals, and alternative antibody formats such as single domain Abs, Fc fusion proteins and other peptide fusions and non-Ig scaffolds. The candidate should have strong expertise in molecular biology and protein biochemistry for application in immunized and human synthetic library design and construction for use in panning and screening of therapeutic modalities, and novel therapeutic formats. Scientist will be responsible for evaluating novel and cutting-edge technology platforms for biologics discovery primarily for applications in IBD and GI related disorders. The candidate will function in a highly matrixed and collaborative environment by interacting and with scientists within the GI Immunology, GI DDU and broader Global Biologics teams within the Takeda organization. The candidate will interface with internal teams and external partners to design and support timely execution of therapeutic programs and strategy. The candidate must have excellent organizational and interpersonal skills with the ability to communicate effectively across functional units.
- Actively survey industry-standard and cutting-edge platforms and evaluates and designs collaborations (including immunization and panning strategies) with external partners (academic and industry)
- Applies antibody discovery/ protein engineering tools and expertise to design and execute humanization and optimization strategies including Fc engineering, liability correction
- Has a strong understanding of phage or any other display technology for high content protein and prototype biologics library generation for combinatorial screening approaches
- Optimize protein and antibody properties through affinity maturation, humanization and directed engineering
- Manages resource allocation across programs based on needs and prioritizations.
- Functions effectively as a part of both functional and cross-functional teams
- Provides in depth analysis and interpretation of data as a part of due diligence and in-house scientific experiments
- As part of a project team partners with the Immunology, DMPK and pre-clinical translational teams to design blue prints and well defined flow schemes for novel biologics discovery based on target biology and mechanism of action for GI applications
- Writes study reports and presents data effectively in all settings with participants of all levels within the organization
- Spends at least 80% time in laboratory, including hands-on mentoring of scientists
- May lead a drug discovery project
- May manage ~2 junior individuals in the team
- Troubleshoot complex problems in creative and effective ways; whenever needed, actively participate with innovation and/ or optimization of established processes to ensure drug design goals are met.
- Maintain familiarity with current scientific literature and contribute to new target concept selection, scientific journal publication and attend/present abstracts at scientific meetings.
- Maintain excellent documentation of all work in the form of laboratory notebooks, technical reports, and presentations to a wider audience.
EDUCATION, EXPERIENCE, KNOWLEDGE AND SKILLS:
- PhD in Biochemistry/Protein Engineering/Structural Biology Immunology with 2-3 years of postdoctoral experience and a minimum of 6+ years of relevant experience, preferably in industry
- Large molecule discovery and engineering experience with a back ground in Immunological mechanisms is highly preferred
- Publications in peer-reviewed journals demonstrating and achievements in the antibody/protein engineering field.
- Significant experience in one or more display technologies and library design and construction required.
- Experience and knowledge in state of the art molecular molecular biology techniques to design, protein expression, construction and optimization of expression vectors for targets (full-length, fragments, mutants, fusion proteins), antibodies, and other proteins is required.
- Adept at bioanalytical and biophysical techniques such as SEC, MALS, DSC
- Familiarity and some experience with Immunology and or immune-oncology MOAs is highly preferred
- Familiarity with flow cytometry and/or sorting is preferred.
- Hands-on expertise with automated platforms is desired.
- Accurate record-keeping skills, and excellent written/verbal communications required.
- Strong team player with a can-do attitude with an ability to thrive in a dynamic biotech- like environment.
- Carrying, handling and reaching for objects up to 25 lbs.
- Working in a lab environment: standing, walking, bending, etc.
- Willingness to travel to various meetings or client sites, including overnight trips. Some international travel may be required.
- Requires approximately 0-5% travel.