Posted to MedZilla on 11/13/2018

Takeda Pharmaceuticals

US-CA, Principal Scientist, Experimental Genome Biologist San Diego, CA R0000690-MZ


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Job Description

Are you looking for a patient-focused company that will inspire you and support your career? If so, be empowered to take charge of your future at Takeda. Join us as a Principal Scientist, Experimental Genome Biologist, Early Target Discovery in our San Diego office.

Here, everyone matters and you will be a vital contributor to our inspiring, bold mission. As a Principal Scientist working in the Early Target Discovery team, you will be empowered in designing experimental follow up to GWAS, whole genome association study and rare variants identified from patient genetics and implement functional characterization strategies.


  • The Principal Scientist of Early Target Discovery, based in San Diego, leads target identification and validation (TIDVAL) project efforts in alignment with Takeda Drug Discovery Unit (DDU) priorities that employ cutting edge technologies in the areas of high throughput molecular biology and functional genomics. The goal of such efforts is the initiation of formal drug discovery campaigns by Takeda Research. The Principal Scientist coordinates the Early Target Discovery s TIDVAL efforts in autoimmune, and/or neurological and rare diseases aligned with Takeda s related Drug Discovery Unit. This individual works collaboratively and effectively with internal and external resources in validating targets and utilizes cutting edge technologies within molecular biology, functional genomics, and patient genetics to build persuasive cases supporting the initiation of drug discovery programs by Takeda Research.


  • Coordinates the Early Target Discovery s TIDVAL efforts in autoimmune, and/or neurological and rare diseases with Takeda s related Drug Discovery Unit.
  • Serves as project leader to identify high quality targets in autoimmune, and/or neurological and rare diseases leading to initiation of discovery programs in alignment with Takeda Drug Discovery Unit priorities.
  • Designs and implement functional characterization strategies for disease associated single nucleotide polymorphisms, SNPs/genes and rare variants identified from patient genetics
  • Designs and executes experiments that decipher functional consequence of rare variant(s) associated with disease(s)/trait(s)
  • Systems-level understanding of integrated genetic, transcriptomic, and phenotypic datasets
  • Identifies opportunities to collaborate with partners (academic, biotech, and CRO) to enhance in-house capabilities. Leads and manages external collaborations effectively
  • Oversees effective and productive execution of collaborations, consortiums, and other external relationships relating to TIDVAL and biomarker discovery.
  • Represents own and group research findings to leadership and project teams.
  • Professionally represents the organization in collaborations, partnership discussions, and external conferences.


  • Ph.D. in Extreme phenotypes/population genetics or Neuroscience or Immunology related discipline with 7+ years of combined post-doctoral training and biotech/pharma industry experience and publication record OR
  • M.S. in Life Science with minimum 10 years of relevant experience and distinguished publication record
  • Has demonstrated independent thought/creativity in genetic disorders in general and technical proficiency and in depth understanding of GWAS and/or extreme phenotype genetics
  • Experimental hands-on experience in some of the following techniques is highly preferred: allelic expression imbalance; experimental demonstration of eQTLs using human biopsies; RNAseq; ChIPseq; ATACseq; Hi C; ChIP-loop; ChIA-PET; WGS/WES; and CRISPR gene editing
  • Experience identifying rare inherited disease variants through whole genome sequencing in patient cohorts with shared ancestry is a plus and not required
  • Track record of working on complex problems, and ability to integrate data from multiple disciplines
  • Knowledge of spatial and temporal patterns of brain gene expression alterations in autism and schizophrenia
  • Strong interpersonal, influencing, and collaboration skills to work in a team-oriented, matrix environment, and the ability to work through conflicts
  • Excellent verbal and written communication skills
  • Highly motivated and flexible with a positive can-do attitude
  • Ability to work in fast-paced, collaborative, team-oriented environment
  • Ability to provide novel creative solutions to challenging problems
  • Desire to learn and tackle new challenges and initiatives


  • Working in cold room (4 C)
  • Able to lift or move up to 10 pounds on a regular basis in the course of daily work
  • Exposure to hazardous/toxic/dangerous chemicals


  • Less than 10% travel, consisting of one to two relevant scientific meetings and/or trips to meet with collaborators and CROs


  • 401(k) with company match and Annual Retirement Contribution Plan
  • Tuition reimbursement
  • Company match of charitable contributions
  • Health & Wellness programs including onsite flu shots and health screenings
  • Generous time off for vacation and the option to purchase additional vacation days
  • Community Outreach Programs

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