Posted to MedZilla on 4/18/2019

Takeda Pharmaceuticals

US-CA, Associate Director, Experimental Genome Biologist San Diego, CA R0000690-MZ


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Job Description

Are you looking for a patient-focused company that will inspire you and support your career? If so, be empowered to take charge of your future at Takeda. Join us as an Associate Director, Experimental Genome Biologist, Early Target Discovery in our San Diego office.

Here, everyone matters and you will be a vital contributor to our inspiring, bold mission. As an Associate Director working in the Early Target Discovery team, you will be empowered in designing experimental follow up to GWAS, whole genome association study and rare variants identified from patient genetics and implement functional characterization strategies.


The Associate Director of Early Target Discovery, based in San Diego, leads target identification and validation (TIDVAL) project efforts in alignment with Takeda Drug Discovery Unit (DDU) priorities that employ cutting edge technologies in the areas of high throughput molecular biology and functional genomics. The goal of such efforts is the initiation of formal drug discovery campaigns by Takeda Research. The Associate Director coordinates the Early Target Discovery s TIDVAL efforts in autoimmune, and/or neurological and rare diseases aligned with Takeda s related Drug Discovery Unit. This individual works collaboratively and effectively with internal and external resources in validating targets and utilizes cutting edge technologies within molecular biology, functional genomics, and patient genetics to build persuasive cases supporting the initiation of drug discovery programs by Takeda Research.


  • Coordinates the Early Target Discovery s TIDVAL efforts in autoimmune, and/or neurological and rare diseases with Takeda s related Drug Discovery Unit.
  • Serves as project leader to identify high quality targets in autoimmune, and/or neurological and rare diseases leading to initiation of discovery programs in alignment with Takeda Drug Discovery Unit priorities.
  • Designs and implement functional characterization strategies for disease associated single nucleotide polymorphisms, SNPs/genes and rare variants identified from patient genetics
  • Designs and executes experiments that decipher functional consequence of rare variant(s) associated with disease(s)/trait(s)
  • Systems-level understanding of integrated genetic, transcriptomic, and phenotypic datasets
  • Identifies opportunities to collaborate with partners (academic, biotech, and CRO) to enhance in-house capabilities. Leads and manages external collaborations effectively
  • Oversees effective and productive execution of collaborations, consortiums, and other external relationships relating to TIDVAL and biomarker discovery.
  • Represents own and group research findings to leadership and project teams.
  • Professionally represents the organization in collaborations, partnership discussions, and external conferences.


  • PhD degree in Genetics or Neuroscience or Immunology) with 10+ years experience , or
  • MS with 14+ years experience, or
  • BS with 16+ years experience
  • 5 years of Industry experience required
  • 5 years of managerial experience required

Technical/Functional (Line) Expertise(Breadth and depth of knowledge, application and complexity of technical knowledge)

  • Experimental hands-on experience in some of the following techniques is highly preferred: allelic expression imbalance; experimental demonstration of eQTLs using human biopsies; RNAseq; ChIPseq; ATACseq; Hi C; ChIP-loop; ChIA-PET; WGS/WES; and CRISPR gene editing
  • Has demonstrated independent thought/creativity in genetic disorders in general and technical proficiency and in depth understanding of GWAS and/or extreme phenotype genetics

Leadership(Vision, strategy and business alignment, people management, communication, influencing others, managing change)

  • Scientific leadership role, setting high standards for effectiveness of execution, and rigor of thought
  • Strong interpersonal, influencing, and collaboration skills to work in a team-oriented, matrix environment, and the ability to work through conflicts
  • Track record of working on complex problems, and ability to integrate data from multiple disciplines

Decision-making and Autonomy(The capacity and authority to make organizational decisions, autonomy in decision-making, complexity of decisions, impact of decisions, problem-soliving)

  • Independently manages workload and expectations
  • Scientific driver for research strategy that impacts group internally and outside area of function

Interaction(The span and nature of one s engagement with others when performing one s job, internal and external relationships)

  • Initiates and leads external interactions and collaborations
  • Frequent contact with internal and external personnel at various management levels

Innovation(The required level of scientific knowledge, knowledge sharing, innovation and risk taking)

  • Determines methods on new assignments; makes strategic recommendations on projects
  • Ability to provide novel creative solutions to challenging problems


  • Working in cold room (4 C)
  • Able to lift or move up to 10 pounds on a regular basis in the course of daily work
  • Exposure to hazardous/toxic/dangerous chemicals


  • Less than 10% travel, consisting of one to two relevant scientific meetings and/or trips to meet with collaborators and CROs


  • 401(k) with company match and Annual Retirement Contribution Plan
  • Tuition reimbursement
  • Company match of charitable contributions
  • Health & Wellness programs including onsite flu shots and health screenings
  • Generous time off for vacation and the option to purchase additional vacation days
  • Community Outreach Programs

Empowering Our People to Shine

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San Diego, CA

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Full time

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